The aim of the project is to find a Competitive inhibitor which will Essay

The labour of the project is to find a Competitive inhibitor which will inhibit the methylation of Protein phosphate 2A (PP2A) Via LCMT-1 - Essay ExampleThis agent that the methylation of PP2A may be an important regulatory mechanism on the condition that the PP2A methylation is tightly regulated.Tamanoi and Clarke (2006, p. 316) further presents that on that point are two main levels of regulation of the PP2A. This is may be achieved either through demethylating enzyme LCMT1 or PME-1 or the regulation at the C-terminal tail of PP2AC site (Tamanoi and Clarke, 2006, p. 316). Furthermore, they advance that the methylation of PP2A can also be regulated or deregulated by certain diseases(Sheng 2013). Seshacharyulu, Pandey, Datta and Batra (2013, p.9) elaborates that PP2A serves to regulate the function by dephosphorylating numerous important cellular molecules much(prenominal) as the p53 and Akt. The PP2A is significant in critical cellular processes including signal transduction, pr oliferation and apoptosis.PP2A is structurally multifarious made up of catalytic, allow and regulatory subunits. The brave out and catalytic sub-units of the PP2A comp turf out of two major isoforms, whereas the regulatory sub-unit has four distinct families of dissimilar isoforms. Of these sub-units, the regulatory sub-unit is considered the most diverse in terms of spatial and temporal specificity.The PP2A usually undergoes certain post-translational changes such as methylation and phosphorylation that serve to regulate the enzymatic activity of PP2A. Certain somatic alterations, mutations and aberrant expression of the PP2A support and regulatory sub-units have been common in a variety of malignancies in humans including skin, breast and lung cancers. This demonstrates that the determination of PP2A as a tumor suppressor (Seshacharyulu et.al 2013). A group of heterogeneous genes encode the individual subunits of the enzyme. This gives rise to a multitude of various PP2A holoe nzyme complexes (Schnthal 2013, p.2). Some of the observations that PP2A puts certain stimulatory and